Asikwazi ukukhawulela i-melanin kumbala wesikhumba lapho sazi ukuthi i-melanin yinhle njengoba inamandla, kepha ngeshwa kube nokuhleleka okuhlelekile, okusenza sikholwe ukuthi i-melanin isebenza kuphela i-pigmentation yesikhumba

Ngakolunye uhlangothi, (abaseNtshonalanga / abaMhlophe) bahlela ingqungquthela ye-melanin minyaka yonke ukuze bafunde futhi bathole indlela yokuzala kabusha i-melanin esele abamnyama banayo. Lesi yisona sizathu futhi esenza abanye bethu manje bafune ukwenza mhlophe isikhumba sethu ukuze balahle i-pigment yethu yemvelo bengazi ukuthi i-melanin, hue, umbala ukumelela okuthile okukhulu kakhulu.

Eqinisweni, abantu "abaMelanized" (abamnyama) abazondwanga ngenxa yombala wesikhumba sabo, kodwa kunalokho ngenxa yemisebenzi eminingi yezempilo abayenzayo futhi ngoba lo mbala uyisithunzi esifanele yonke imisebenzi yaso organic.